Research

Introduction

All cells respond to changes in their environment, and information processing is accomplished by the underlying signalling networks. A major challenge in contemporary biophysics is to quantitatively understand the algorithms of these signalling networks.

Using microoganism motile behavior as an example，we combine a multitude of optical methods(TIRF, FRET, Laser darkfield, Super-resolution techniques, Optical tweezer), microfludics, and molecular biology techniques，with statistical mechanics modelling, to understand microoganism motile behavior from the level of molecular motors to the level of signalling networks.

Projects

• Bacterial motile behavior and the flagellar rotary motor

• Bacterial chemotaxis

• The c-di-GMP network

• Sperm motility and temperature sensing