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2006 U. of Rochester, Rochester, NY
Ph.D. in Cell, Molecular and Developmental Biology

2001 U. of Rochester, Rochester, NY

M.S. in Cell, Molecular and Developmental Biology

1999 Beijing Normal University, Beijing, China
M.S. in Molecular Cell Biology

1996 Beijing Normal University, Beijing, China
B.S. in Biology

2012/12 – Selected Candidate ,Chinese Thousand Youth Talents Plan
Professor & Director, School of Life Sciences,USTC

11/2012- Research specialist, HHMI at UCSD

3/2011 – 10/2012 Research Associate, UC, San Diego. Mentor: Dr. Michael G. Rosenfeld

• Genotoxic stress-induced activation of SIRT1 expression and underlying mechanisms of myocardial infarction.
• Genome-wide short- and long- range interactions in transcriptional regulation.

3/2008 – 2/2011 Postdoctoral fellow, Cancer Research Institute. Mentor: Dr. Michael G. Rosenfeld
• Genotoxic stress-induced activation of SIRT1 expression.
• Genomic approaches to prostate cancer hormone resistance.
• Non-coding RNAs mechanisms in transcriptional regulation.

9/2006 – 2/2008 Research Associate, HHMI, Mentor: Dr. Michael G. Rosenfeld
• Stress induced ncRNAs regulating TLS to mediate its transcriptional repression.

9/1999 – 8/2006 Research Assistant, Department of Biology, U. of Rochester
• Established the basis for the first inducible-repressible promoter system in Tetrahymena that is now widely utilized.
• Demonstrated for the first time that the phosphorylation state of linker histone H1 can be targeted to a specific promoter where it likely regulates gene-specific transcription.
• Revealed that elimination of the H2A.X phosphorylation in the SQ motif causes DNA damage in both macronuclei and micronuclei in T. thermophila.
• Determined functions of a newly discovered histone H2A variant in T. thermophila.

2/1999 – 8/1999 Research Associate, Beijing Institute of Infectious Diseases
• Experimental trial before clinical practice of the adenovirus-mediated transfer of p53, GM-CSF and B7-1 genes for gene therapy against hepatocellular carcinoma.

9/1996 – 1/1999 Research Assistant, Ministry of Education key laboratory of cell proliferation and regulation, Beijing Normal University
• Developed two in vitro erythropoiesis models.
• Demonstrated important function of the UPP pathway in erythropoiesis.

2012 Youth Thousand Talents Program Award

2010 ASBMB 2010 Graduate/Postdoctoral Travel Award.

2010 Scholar-in-Training Award Supported by AACR-Aflac, Inc.

2008-2011 Cancer Research Institute/Irvington Institute Postdoctoral Fellowship

2001 Biology Department Graduate Student Teaching Award, U. of Rochester

1996 Special Award for the Most Outstanding Graduates, Awarded by Beijing Government

1995 Science and Technology Fellowship, Beijing Normal University

Shang, Y., Song, X., Bowen, J., Gao, Y., Gaertig, J. and Gorovsky, M.A. A robust inducible-repressible promoter greatly facilitates somatic and germline knockouts, over-expression and analysis of γ-tubulin function in Tetrahymena Thermophila. FASEB Summer Research Conference – The 9th International Meeting on Ciliate Molecular Biology. Saxtons River, VT, July 28-Aug. 2, 2001.

Song, X. and Gorovsky, M.A. Histone H1 in a Specific Region of the CDC2-1 Promoter is De-phosphorylated When the Gene is Inactive. FASEB Summer Research Conference – The 10th International Meeting on Ciliate Molecular Biology. Saxtons River, VT, July 19-24, 2003.

Song, X. and Gorovsky, M.A. Histone H1 De-phosphorylation is Specific to the Promoter Region of the CDC2-1 Gene When the Gene is Inactive. 22nd Summer Symposium in Molecular Biology – Chromatin Structure and Function. Pennsylvania State U., PA, July 30-Aug. 2, 2003.

Song, X. and Gorovsky, M.A. In vivo Functional Studies of the HTA.Y Gene in Tetrahymena thermophila. 2005 FASEB Summer Research Conference – Ciliate Molecular Biology. II Ciocco, Lucca, Toscana, Italy. August 3-8, 2005.

Song, X*. , Miook Cho*, Jeehae Han, Helen Hazuda, Ravindranath Duggirala, John Blangero, Michael G. Rosenfeld, and Yousin Suh. Molecular mechanisms of a disease susceptibility variant of SIRT1: Genotoxic stress-induced, CTCF-dependent activation of SIRT1 gene expression. 2010 ASBMB 2010 Annual Meeting, Anaheim, CA, April 24-28, 2010.* Equal contributors.

Cao Jun
Wu Yan

2013
2014

2013
2014

2014

2014

国家自然科学基金（NSFC）
原生动物嗜热四膜虫新月小核的三维空间转录调控分子机制
重大科学研究计划（973）
长非编码 RNA 在精子发生中的功能及机制
中组部“青年千人计划”
国家国际科技合作专项
生殖健康研究：四膜虫减数分裂基因功能分析
中央高校青年创新基金
美国癌症研究中心博士后奖学金 (Cancer Research Institute Fellowship）
Genomic approaches to innate immunity dependent hormone resistance in prostate cancer

1. Liu Z, Merkurjev D, Yang F, Li W, Oh S, Friedman MJ, Song X, Zhang F, Ma Q, Ohgi KA, Krones A, Rosenfeld MG. Enhancer Activation Requires trans-Recruitment of a Mega Transcription Factor Complex. Cell.. 2014, 159(2):358-73.

2. Li W, Notani D, Ma Q, Tanasa B, Nunez E, Chen AY, Merkurjev D, Zhang J, Ohgi K, Song X, Oh S, Kim HS, Glass CK, Rosenfeld MG. Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation. Nature. 2013, 498(7455):516-20.

3. Song, X., Bowen J., Miao W., and Gorovsky, M.A. The non-histone, N-terminal tail of an essential, chimeric H2Avariant regulates mitotic H3 S10 de-phosphorylation. Genes & Development. 2012, 26(6):615-29.

4. Song X*., Wang X*., Arai S. and Kurokawa R. Promoter-Associated Noncoding RNA from the CCND1 promoter. Methods in Molecular Biology. 2012, 809:609-22. *共第一作者

5. Harismendy O.*, Notani D.*, Song X., Rahim N.G., Tanasa B., Heintzman N., Ren B., Fu X., Topol E., Rosenfeld M.G., and Frazer K.A. 9p21 DNA variants associated with coronary artery disease impair interferon-γ signalling response. Nature. 2011, 470(7333):264-8. *共第一作者。

6. Wang X*. and Song X*., Glass C.K., and Rosenfeld M.R. The long arm of long non-coding RNAs: Roles as sensors regulating gene transcriptional programs. Cold Spring Harb Perspect Biol. 2011 3(1):a003756. doi: 10.1101/cshperspect.a003756. *共第一作者。收编在第四版《The RNA World》。

7. Wang X., Arai S*., Song X.*, Reichart D., Du K., Pascual G., Tempst P., Rosenfeld M.R., Glass C.K., and Kurokawa R. Stress-induced Non-coding RNAs Allosterically Regulate a HAT-inhibitory RNA Binding Protein to Mediate Transcriptional Repression. Nature. 2008, 454(7200):126-30. *共第二作者。

8. Song, X.*, Gjoneska E*., Ren Q*., Allis C.D., and Gorovsky, M.A. Phosphorylation of H2A.X at SQ motif is Required for Proper Meiosis and Mitosis in Tetrahymena thermophila. Mol Cell Biol. 2007, 27(7):2648-60. *共第一作者。

9. Song, X. and Gorovsky, M.A. Unphosphorylated H1 is Localized in a Specific Region of the Promoter when CDC2 is Down-regulated during Starvation. Mol Cell Biol. 2007, 27(5):1925-33.

10. Dou, Y.*, Song, X.*, Liu, Y., and Gorovsky, M.A. The H1 Phosphorylation State Regulates Expression of CDC2 and Other Genes in Response to Starvation in Tetrahymena thermophila. Mol Cell Biol. 2005, 25(10):3914-22. *共第一作者。

11. Liu, Y., Song, X., Gorovsky, M.A., and Karrer, K.M. Elimination of foreign DNA during somatic differentiation in Tetrahymena thermophila shows position effect and is dosage dependent. Eukaryot Cell. 2005, 4(2):421-31.

12. Shang, Y., Song, X., Bowen, J., Corstanje, R., Gao, Y., Gaertig, J., and Gorovsky, M.A. A robust inducible-repressible promoter greatly facilitates gene knockouts, conditional expression, and overexpression of homologous and heterologous genes in Tetrahymena thermophila. PNAS. 2002, 99(6):3734-9.

Xiaoyuan Song

Cao Jun

Wu Yan

Xu Qianlan

Zhang Yan

Wang Fei

Luo Zhengyu

Cheng Qinyu

Ke Shengwei

Zhang Jinsong

Chen Zhaoxiong

Zhang Ran

Peng Qi

Wang Ruoyu

Mohammed Azhar

Fan Xiaolan

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