课题组新网址请见: https://faculty.ustc.edu.cn/wangqian123
Wang Research Group
Computational and Theoretical Biophysics
诚聘研究生及博士后,请联系wqq@ustc.edu.cn
研究生不需任何前置生物学知识
PI: 汪骞
2020年4月入职中国科学技术大学物理系,中科院百人计划,特任研究员/博导
2003-2007/6 中国科学技术大学近代物理系,学士
2007-2012/5 美国休斯敦大学物理系,博士
2012-2020/1 美国德州大学医学部、美国莱斯大学理论生物物理学中心,博士后
研究兴趣:结合物理统计规律、分子动力学模拟、机器学习等手段,理解生物系统的动力学特性和功能实现。物理、化学、生物、医学的交叉领域。
课题简介:
1) 纳米分子机器
细胞内存在着一类将化学能转为动能的特殊蛋白质—纳米分子机器。我们致力于研究纳米分子机器是如何高效地完成重要的生理功能,以及相关疾病的机理和治疗。
2) 蛋白质动力学
历经50年的研究历程,现代分子生物学“皇冠上的明珠”—蛋白质折叠问题依然未被解决。机器学习的快速发展为解决这一难题增添了重要的思路。我们希望开发新式算法,根据蛋白质一级序列来预测其三级结构、动力学性质、和功能。
3) 单碱基编辑系统的优化
基因编辑技术是对生物医疗领域一场颠覆性的革命。在此变革之际,我们致力于研究基因编辑的调控机制,对现有基因编辑系统展开优化,提高其效率和精度,推动其临床应用。
代表性工作:
After joining USTC in 2020 (# co-first author; * co-corresponding author):
- Q. Wang#*, Lin Wang#, Yumin Zhang#, XiangLei Zhang, Leike Zhang, Weijuan Shang* and Fang Bai*, "Probing the Allosteric Inhibition Mechanism of a Spike Protein Using Molecular Dynamics Simulations and Active Compound Identifications", Journal of Medicinal Chemistry, 65(4), 2827-2835 (2022)
- Q. Wang#*, Jie Yang#, Zhicheng Zhong, Jeffrey A. Vanegas, Xue Gao*, Anatoly B. Kolomeisky*, "A General Theoretical Framework to Design Base Editors with Reduced Bystander Effects", Nature Communications, 12, 6529 (2021)
Before 2020 (# co-first author; * co-corresponding author):
- Q. Wang, M. Chen, N. P. Schafer, C. Bueno, P. G. Wolynes, M. N. Waxham and M. S. Cheung, “Assemblies of Calcium/Calmodulin Dependent Kinase II with Actin and Their Dynamic Regulation by Calmodulin in Dendritic Spines”, PNAS, 116 (38), 18937-18942 (2019)
- Q. Wang, B. Jana, M. R Diehl, M. S. Cheung, A. B. Kolomeisky and J. N. Onuchic, “Molecular Mechanisms of the Interhead Coordination by Interhead Tension in Cytoplasmic Dyneins”, PNAS, 115 (40), 10052-10057 (2018)
- Q. Wang, M. R. Diehl, B. Jana, M. S. Cheung, A. B. Kolomeisky and J. N. Onuchic, “Molecular Origin of the Weak Susceptibility of Kinesin Velocity to Loads and its Relation to the Collective Behavior of Kinesins”, PNAS, 114, E8611–E8617 (2017)
- Q. Wang, R. N. Irobalieva, W. Chiu, M. F. Schmid, J. M. Fogg, L. Zechiedrich, and B. Montgomery Pettitt, “Influence of DNA sequence on the structure of minicircles under torsional stress”, Nucleic Acids Research, 45 (13), 7633-7642 (2017)
- Q. Wang#, P. Zhang#, S. Tripathi, L. Hoffman, L. Yin, M. N. Waxham, M. S. Cheung, "Protein recognition and selection through conformational and mutually induced fit", PNAS, 110, 20545-20550 (2013)
- Q. Wang and A. B. Kolomeisky, “Theoretical Analysis of Run Length Distributions for coupled Motor Proteins”, Journal of Physical Chemistry B, 123 (27), 5805-5813 (2019)
- Q. Wang and B. Montgomery Pettitt, “Sequence Affects the Cyclization of DNA Minicircles”, Journal of Physical Chemistry Letter, 7, pp 1042–1046 (2016)
- Q. Wang and B. Montgomery Pettitt, “Modeling DNA Thermodynamics under Torsional Stress”, Biophysical Journal, 106, 1182-1193 (2014)
- Q. Wang and M. S. Cheung, “A Physics-based Approach of Coarse-graining the Cytoplasm of E. coli (CGCYTO)”, Biophysical Journal, 102, 2353-2361 (2012)
- Q. Wang, Kao-Chen Liang, A. Czader, M. N. Waxham, M. S. Cheung, "The effect of macromolecular crowding, ionic strength and calcium binding on calmodulin dynamics", PLoS Computational Biology, 7: e1002114 (2011)