课题组新网址请见: https://faculty.ustc.edu.cn/wangqian123

 

Wang Research Group

Computational and Theoretical Biophysics

诚聘研究生及博士后，请联系wqq@ustc.edu.cn

研究生不需任何前置生物学知识

PI: 汪骞

2020年4月入职中国科学技术大学物理系，中科院百人计划，特任研究员/博导

2003-2007/6 中国科学技术大学近代物理系，学士

2007-2012/5 美国休斯敦大学物理系，博士

2012-2020/1 美国德州大学医学部、美国莱斯大学理论生物物理学中心，博士后

 

研究兴趣：结合物理统计规律、分子动力学模拟、机器学习等手段，理解生物系统的动力学特性和功能实现。物理、化学、生物、医学的交叉领域。

 

课题简介：

1) 纳米分子机器

细胞内存在着一类将化学能转为动能的特殊蛋白质—纳米分子机器。我们致力于研究纳米分子机器是如何高效地完成重要的生理功能，以及相关疾病的机理和治疗。

2) 蛋白质动力学

历经50年的研究历程，现代分子生物学“皇冠上的明珠”—蛋白质折叠问题依然未被解决。机器学习的快速发展为解决这一难题增添了重要的思路。我们希望开发新式算法，根据蛋白质一级序列来预测其三级结构、动力学性质、和功能。

3) 单碱基编辑系统的优化

基因编辑技术是对生物医疗领域一场颠覆性的革命。在此变革之际，我们致力于研究基因编辑的调控机制，对现有基因编辑系统展开优化，提高其效率和精度，推动其临床应用。

 

代表性工作：

After joining USTC in 2020 (# co-first author; * co-corresponding author):

  1. Q. Wang#*, Lin Wang#, Yumin Zhang#, XiangLei Zhang, Leike Zhang, Weijuan Shang* and Fang Bai*, "Probing the Allosteric Inhibition Mechanism of a Spike Protein Using Molecular Dynamics Simulations and Active Compound Identifications", Journal of Medicinal Chemistry, 65(4), 2827-2835 (2022)
  2. Q. Wang#*, Jie Yang#, Zhicheng Zhong, Jeffrey A. Vanegas, Xue Gao*, Anatoly B. Kolomeisky*, "A General Theoretical Framework to Design Base Editors with Reduced Bystander Effects", Nature Communications, 12, 6529 (2021)

Before 2020 (# co-first author; * co-corresponding author):

  1. Q. Wang, M. Chen, N. P. Schafer, C. Bueno, P. G. Wolynes, M. N. Waxham and M. S. Cheung, “Assemblies of Calcium/Calmodulin Dependent Kinase II with Actin and Their Dynamic Regulation by Calmodulin in Dendritic Spines”, PNAS, 116 (38), 18937-18942 (2019)
  2. Q. Wang, B. Jana, M. R Diehl, M. S. Cheung, A. B. Kolomeisky and J. N. Onuchic, “Molecular Mechanisms of the Interhead Coordination by Interhead Tension in Cytoplasmic Dyneins”, PNAS, 115 (40), 10052-10057 (2018)
  3. Q. Wang, M. R. Diehl, B. Jana, M. S. Cheung, A. B. Kolomeisky and J. N. Onuchic, “Molecular Origin of the Weak Susceptibility of Kinesin Velocity to Loads and its Relation to the Collective Behavior of Kinesins”, PNAS, 114, E8611–E8617 (2017)
  4. Q. Wang, R. N. Irobalieva, W. Chiu, M. F. Schmid, J. M. Fogg, L. Zechiedrich, and B. Montgomery Pettitt, “Influence of DNA sequence on the structure of minicircles under torsional stress”, Nucleic Acids Research, 45 (13), 7633-7642 (2017)
  5. Q. Wang#, P. Zhang#, S. Tripathi, L. Hoffman, L. Yin, M. N. Waxham, M. S. Cheung, "Protein recognition and selection through conformational and mutually induced fit", PNAS, 110, 20545-20550 (2013)
  6. Q. Wang and A. B. Kolomeisky, “Theoretical Analysis of Run Length Distributions for coupled Motor Proteins”, Journal of Physical Chemistry B, 123 (27), 5805-5813 (2019)
  7. Q. Wang and B. Montgomery Pettitt, “Sequence Affects the Cyclization of DNA Minicircles”, Journal of Physical Chemistry Letter, 7, pp 1042–1046 (2016)
  8. Q. Wang and B. Montgomery Pettitt, “Modeling DNA Thermodynamics under Torsional Stress”, Biophysical Journal, 106, 1182-1193 (2014)
  9. Q. Wang and M. S. Cheung, “A Physics-based Approach of Coarse-graining the Cytoplasm of E. coli (CGCYTO)”, Biophysical Journal, 102, 2353-2361 (2012)
  10. Q. Wang, Kao-Chen Liang, A. Czader, M. N. Waxham, M. S. Cheung, "The effect of macromolecular crowding, ionic strength and calcium binding on calmodulin dynamics", PLoS Computational Biology, 7: e1002114 (2011)