魏熹 Xi Wei
特任副研究员
Associate Professor of Computer Science
中国科学技术大学计算机科学与技术学院
University of Science and Technology of China (USTC)
Email: wxi@ustc.edu.cn
电话：+86 0551 63600052
Address：School of Computer Science and Technology, University of Science and Technology of China (USTC), Hefei, Anhui, 230027
招生计划
现计划招收硕士生1-2名。理工科专业，背景不限。欢迎充满好奇心和创造力的你！
教育经历
– PhD Biomedical Engineering – New York University 2018
– MS Biomedical Engineering – New York University 2010
– Diploma 生物技术 – 中国药科大学 2008
工作经历
2010.12-2013.09 Junior Research Scientist, NYU College of Dentistry
2018.04-2018.11 Postdoctoral Researcher, KTH Royal Institute of Technology
2019.01- 至今 特任副研究员 中国科学技术大学计算机科学与技术学院
研究方向
本人研究领域处于微系统制造，电子信息技术以及生物医学工程的密集交叉点，研究内容立足于微流控技术，围绕微型医用诊疗系统展开，主要应用于超低生物标记物的体外检测和适用于微创手术递送的体内载药系统两大方面。
在研课题
1) 体外检测芯片-用于检测超低浓度标记物的生物富集芯片
针对于临床上与疾病相关的重要标记物普遍存在的浓度极低，取样总量小，易造成漏检误检的挑战，本课题重点研究新型微流控富集器件，将低浓度目标物富集至微流通道中特定区域，大幅度提高其局部浓度，从而突破物质传递限制，使目待测标物跃升至下游检测方法的阈值之上，提高样品检测的灵敏度和速率。
2）微创抗癌疗法-用于实现定向化疗的自数字化细胞承载微型胶囊
可定向的化疗手段一直是临床尚未攻克的难题;尤其是在针对于对放射疗法不敏感，化疗作为主要治疗途径的恶性肿瘤，现有的化疗手段难以发挥抗癌药物的最大功效。本课题提出新型细胞胶囊制造手段，将转染后具有药物转化功能的治疗细胞胶囊化后通过微创手段植入至肿瘤周围的血管分支，可定向活化周围前体药物，达到在低剂量使用前体药物下取得肿瘤组织高活化药物浓度，有效进行抗癌治疗。
已发表论文 (Google Scholar page)
期刊论文
1. Xi Wei#; Vu Q.Do; Sang V.Pham; Diogo Martins; Yong-Ak Song*, A Multiwell-Based Detection Platform with Integrated PDMS Concentrators for Rapid Multiplexed Enzymatic Assays, Scientific Reports, 2018.07.17, 8(1): 10772
2. Lucia S.Cheung#; Xi Wei; Diogo Martins; Yong-Ak Song*，Rapid Detection of Exosomal MicroRNA Biomarkers by Electrokinetic Concentration for Liquid Biopsy on Chip, Biomicrofluidics, 2018.1.2, 12: 014104
3. Xi Wei#; Prabodh Panindre; Qi Zhang; Yong-Ak Song*, Increasing the Detection Sensitivity for DNA-Morpholino Hybridization in Sub-Nanomolar Regime by Enhancing the Surface Ion Conductance of PEDOT:PSS Membrane in a Microchannel, ACS Sensors, 2016.07.05, 1(7): 862~865
4. Diogo Martins#; Xi Wei; Rastislav Levicky; Yong-Ak Song*, Integration of Multiplexed Microfluidic Electrokinetic Concentrators with a Morpholino Microarray via Reversible Surface Bonding for Enhanced DNA Hybridization, Analytical Chemistry, 2016.2.25, 88(7): 3539~354
5. Xi Wei#; S. Pushalkar; C. Estilo; C. Wong; A. Farooki; M. Fornier; G. Bohle; J. Huryn; Y. Li; S. Doty; D. Saxena*, Molecular Profiling of Oral Microbiota in Jawbone Samples of Bisphosphonate-Related Osteonecrosis of the Jaw, Oral Diseases, 2012.2.3, 18: 602~612
会议报告
1. Xi Wei; Yong-Ak Song, ISAAC-X:An Integrated System for Accelerating Assays with Concentrators, The 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS), Savannah, Georgia, 2017.10. 22-2017.10.26
2. Xi Wei; Yong-Ak Song, A Multi-well Based Detection Platform with Integrated PDMS Concentrators for Rapid Multiplexed Enzymatic Assays, The 21sInternational Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS), Savannah, Georgia , 2017.10.22-2017.10.26
3. Xi Wei; Qi Zhang; Yong-Ak Song, Increasing the Detection Sensitivity for DNA-Morpholino Hybridization in Sub-Nanomolar Regime by Enhancing the Surface Ion Conductance of PEDOT:PSS Membrane in a Microchannel, The 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS), Dublin, 2016.10.9-2016.10.13
4. Diogo Martins; Xi Wei; Rastislav Levicky; Yong-Ak Song, Accelerating the Mass Transport of DNA Biomolecules Onto DNA Microarray for Enhanced Detection by Electrokinetic Concentration in a Microfluidic Chip, ASME 2016 5th International Conference on Micro/Nanoscale Heat and Mass Transfer (MNHMT), Biopolis, 2016.1.4-2016.1.6
所获奖项
Horizon 2020, Marie-Sklodowska-Curie Actions The Seal of Excellence Award, 2019
Postdoctoral Scholarship, KTH Royal Institute of Technology, Stockholm, Sweden, 2018-2019
Finalist, Shark Tank Competition, MicroTAS 21st International Conference, Savannah, USA, 2017
Best Paper Award, ASME Micro/Nanoscale Heat and Mass Transfer Conference (MNHMT), Singapore, 2016
Global PhD Student Fellowship, New York University, 2014-2018
