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肿瘤微环境和代谢实验室

Publications

1. Li ST, Huang D, Shen S, Cai Y, Xing S, Wu G, Jiang Z, Hao Y, Yuan M, Wang N, Zhu L, Yan R, Yang D, Wang L, Liu Z, Hu X, Zhou R, Qu K, Li A, Duan X*, Zhang H*, Gao P*. Myc-mediated SDHA acetylation triggers epigenetic regulation of gene expression and tumorigenesis. Nature Metabolism, 2020 March 16; 2:256-269.

2. Xing S, Li Z, Ma W, He X, Shen S, Wei H, Li ST, Shu Y, Sun L, Zhong X, Huangfu Y, Su L, Feng J, Zhang X, Gao P, Jia WD, Zhang H*. DIS3L2 promotes progression of hepatocellular carcinoma via hnRNP U-mediated alternative splicing. Cancer Res. 2019 Oct 1;79(19):4923-4936.

3. Zhang Y, Li C, Hu C, Wu Q, Cai Y, Xing S, Lu H, Wang L, Huang, Sun L, Li T, He X, Zhong X, Wang J, Gao P, Smith ZJ, Jia W,Zhang H*. Lin28 enhances de novo fatty acid synthesis to promote cancer progression via SREBP-1. EMBO Rep. 2019 Oct 4;20(10):e48115. doi: 10.15252/embr.201948115.

4. Liu X, Shen S, Wu P, Li F, Liu X, Wang C, Gong Q, Wu J, Yao X, Zhang H*, Shi Y*. Structural insights into dimethylation of 12S rRNA by TFB1M: indispensable role in translation of mitochondrial genes and mitochondrial function. Nucleic Acids Res. 2019 Aug 22;47(14):7648-7665.

5. Zhong X, Cui P, Cai Y, Wang L, He X, Long P, Lu K, Yan R, Zhang Y, Pan X, Zhao X, Li W, Zhang H*, Zhou Q*, Gao P*. Mitochondrial Dynamics Is Critical for the Full Pluripotency and Embryonic Developmental Potential of Pluripotent Stem Cells. Cell Metabolism 2019 Apr 2;29(4):979-992.

6. Ma X, Wang L, HuangD , Li Y, Yang D, Wang J, Gao P and Zhang H*. Polo-like Kinase 1 Coordinates Biosynthesis during Cell Cycle Progression by Directly activating. Pentose phosphate pathway. Nature Communications 2017 Nov 15;8(1):1506.

7. Zhong X, Tian S, Zhang X, Diao X, Dong F, Yang J, Li Z, Sun L, Wang L, He X, Wu G, Hu X, Wang L, Song L, Zhang H*, Pan X, Li A, And Gao P. CUE domain-containing protein 2 promotes the Warburg effect and tumorigenesis. EMBO Reports (2017) 18: 809-825.

8. Wu G, Yuan M, Shen S, Ma X, Fang J, Zhu L, Sun L, Liu Z, He X, Huang D, Li T, Li C, Wu J, Hu X, Li Z, Song L, Qu K, Zhang H* And Gao P. Menin enhances c-Myc-mediated transcription to promote cancer progression. Nat. Commun. 8, 15278 doi: 10.1038/ncomms15278 (2017).

9. Wang L, Zhang T, Wang L, Cai Y, Zhong X, He X, Hu L, Tian S, Wu M, Hui L, Zhang H* And Gao P. Fatty acid synthesis is critical for stem cell pluripotency via promoting mitochondrial fission. The EMBO Journal (2017) 36: 1330-1347

10. Huang D, Li T, Wang L, Zhang L, Yan R, Kui Li, Xing S, Wu G, Hu L, Jia W, Lin S, Dang CV, Song L, Gao P, Zhang H*. Hepatocellular carcinoma redirects to ketolysis for progression under nutrition stress. Cell Research 2016 Sep 20. 26(10), 1112-1130.

11. Sun L, Song L, Wan Q, Wu G, Li X, Wang Y, Wang J, Liu Z, Zhong X, He X, Shen S, Wang Y, Gao P*, Tang H, Zhang H*. cMyc-Mediated Activation of Serine Biosynthesis Pathway is Critical for Cancer Progression under Nutrient Deprivation Conditions. Cell Research 2015 Apr;25(4):429-44.

12. Cao Y, Guo W, Tian S, He X, Wang X, Liu X, Gu K, Ma X, Huang D, Hu L, Cai Y, Zhang H, Wang Y And Gao P. miR-290/371-Mbd2-Myc circuit regulates glycolytic metabolism to promote pluripotency. The EMBO Journal (2015) 34: 609-623.

13. Yuan Y, Wang L, Du W, Ding Z, Zhang J, Han T, An L, Zhang H* and Liang L*. Intracellular Self-Assembly of Taxol Nanoparticles for Overcoming Multidrug Resistance. Angew. Chem. Int. Ed. 2015, 54, 9700-9704.

14. Ma X, Li C, Sun L, Huang D, Li T, He X, Wu G, Yang Z, Zhong X, Song L, Gao P, Zhang H*. Lin28/let-7 axis regulates aerobic glycolysis and cancer progression via PDK1. Nature Communications 2014 Oct 10;5:5212.

15. Huang D, Li T, Li X, Zhang L, Sun L, He X, Zhong X, Jia D, Song L, Semenza GL, Gao P, and Zhang H*. HIF-1-Mediated Suppression of Acyl-CoA Dehydrogenases and Fatty Acid Oxidation Is Critical for Cancer Progression. Cell Reports 8, 1–13, September 25, 2014

16. Huang D, Li T, Li X, Zhang L, Sun L, He X, Zhong X, Jia D, Song L, Semenza GL, Gao P and Zhang H*. HIF-1-Mediated Suppression of Acyl-CoA Dehydrogenases and Fatty Acid Oxidation is Critical for Cancer Progression. Cell Reports 2014 Sep 25;8(6):1930-42 .

17. Zhang H, Gao P, Fukuda R, Kumar G, Krishnamachary B, Dang CV, Semenza GL. HIF-1 represses mitochondrial mass and respiration in VHL-null renal cell carcinoma. Cancer Cell 11(5):407-20,2007.

18. Fukuda R, Zhang H, Kim JW, Shimoda L, Dang CV, Semenza GL. HIF-1 RegulatesCytochrome Oxidase Subunits to Optimize Efficiency of Respiration in Hypoxic Cells. Cell 129(1):111-22, 2007.

19. Zhang H, Qian DZ, Tan Y, Lee K,Gao P, Ren YR,Rey S, Hammers H, Chang D,1 Pili R, Dang CV, Liu JO and Semenza GL. Digoxin and Other Cardiac Glycosides Inhibit HIF-1a Synthesis and Block Tumor Growth.?PNAS?105 (50):19579-86 (2008).

20. Zhang H, Bosch-Marce M, Shimoda LA, Tan YS, Baek JH, Wesley JB, Gonzalez FJ, Semenza GL. (2008) Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia.?J Biol Chem. 283 (16):10892-903.

21. Gao P,Zhang H, Dinavahi R, Li F, Xiang Y, Raman V, Bhujwalla ZM, Felsher DW, Cheng L, Pevsner J, Lee LA, Semenza GL, Dang CV. (2007) HIF-dependent Anti-tumorigenic Effect of Anti-oxidants In Vivo.?Cancer Cell. 12(3):230-8.