Structure tailoring and proximity effect of dimeric G-quadruplexes and i-motifs
Tailoring the structures of dimeric G-quadruplexes and i-motifs to modulate their folding topologies, and then employing the designed structures as switching tools to construct diverse DNA nanodevices;

Utilizing the proximity effect of dimeric G-quadruplexes and i-motifs to build controllable sensing nanoplatforms for intracellular analysis of mRNAs, miRNA, ATP, and other targets.

Quadruplex DNAs modulated framework nucleic acid (FNA) nanodevices for cellular logic computation
Utilizing G-quadruplexes and i-motifs as controlling units to modulate the structural changes of framework nucleic acid (FNA) nanodevices, and thereby enabling their logic response to external stimuli;

Engineering cellular computing circuits with FNA logic devices for environment recognition via employing cellular endogenous components as the inputs to in situ activate logic circuits.

Spherical nucleic acid enzymes (SNAzymes) catalyzed gene detection
Constructing spherical nucleic acid enzymes (SNAzymes) derived from a dense layer of G-quadruplex DNAzymes DNAzyme formed on the gold nanoparticle core, with super catalytic activity and improved nuclease resistance;

Applying SNAzymes to the catalyzed amplification analysis of disease-related miRNAs and other nucleic acid biomarkers.