INTRODUCTION
Our Laboratory is now working on exploiting the functional diversity of non-coding RNAs (ncRNAs) and systems biology of virus-host interaction
我们实验室主要应用分子生物学、高通量测序和生物信息学等研究手段，研究病毒与宿主互作中的蛋白和非编码RNA功能及其分子作用机制；发展新病毒鉴定方法，并用于病毒宏基因组研究。目前主要研究方向包括：
1、果蝇天然免疫抗病毒机制研究
果蝇是研究天然免疫抗病毒机制的模式生物，在果蝇参与病毒互作的蛋白在哺乳动物中具有较高的保守性。目前研究表明，参与果蝇抗病毒先天免疫通路主要有：RNAi通路、JAK-STAT通路、Toll通路、Imd通路。随着对果蝇天然免疫机制研究的深入，不断发现新的调控分子和效应分子参与果蝇的天然免疫反应。
实验室相关论文：
1. Zhang L，Xu W，Gao X，Li W，Qi S，Guo D，Ajayi E，Ding SW，Wu Q&；LncRNA Sensing of a Viral Suppressor of RNAi Activates Non-canonical Innate Immune Signaling in Drosophila， Cell Host & Microbe, 2020, 27(1)：115-128.
2. Han Y&, Wu Q&, Ding SW&. Templating Antiviral RNAi in Insects. Cell Host Microbe. 2018, 23(3):290-292.
3. Zhang Q, Zhang L, Gao X, Qi S, Chang Z, Wu Q&. DIP1 plays an antiviral role against DCV infection in Drosophila melanogaster. Biochem Biophys Res Commun. 2015, 460(2):222-6.
4. Han YH#, Luo YJ#, Wu Q# &, Jovel J, Wang XH, Aliyari R, Han C, Li WX, Ding SW&. RNA-based immunity terminates viral infection in adult Drosophila in the absence of viral suppression of RNA interference: characterization of viral small interfering RNA populations in wild-type and mutant flies. J Virol. 2011, 85(24):13153-63. （# 共同第一作者， &共同通讯作者)
5. Wu Q, Wang X, Ding SW. Viral suppressor of RNA-based viral immunity: Host targets. Cell Host & Microbe. 2010, 8(1):12-5.
6. Aliyari R#, Wu Q#, Li HW, Wang XH, Green L, Han C, Li WX, Ding SW. Mechanism of induction and suppression of antiviral immunity directed by small RNA in Drosophila. Cell Host & Microbe 2008, 4: 387-397. (# 共同第一作者)
2、白背飞虱与病毒互作机制研究
我国为害水稻的稻飞虱主要有三种，分别是白背飞虱、灰飞虱以及褐飞虱。 白背飞虱还是是传播南方黑条矮缩病毒(SRBSDV)的高效传播载体，最近几年SRBADV爆发给我国水稻产量带来了巨大的经济损失。我们研究白背飞虱获毒以后的SRBSDV与宿主免疫系统的互作机制，特别关注长链非编码RNA在其中的功能和作用机制。
实验室相关论文：
1. Gao X, Fu Y, Ajayi OE, Guo D, Zhang L, Wu Q&. Identification of genes underlying phenotypic plasticity of wing size via insulin signaling pathway by network-based analysis in Sogatella furcifera. BMC Genomics. 2019, 20(1):396.
2. Chang ZX, Ajayi OE, Guo DY, Wu Q&. Genome-wide characterization and developmental expression profiling of long non-coding RNAs in Sogatella furcifera. Insect Sci. 2019.
3. Zeng Z, Fu Y, Guo D, Wu Y, Ajayi OE, Wu Q&. Bacterial endosymbiont Cardinium cSfur genome sequence provides insights for understanding the symbiotic relationship in Sogatella furcifera host. BMC Genomics. 2018, 19(1):688.
4. Wang L, Tang N, Gao X, Chang Z, Zhang L, Zhou G, Guo D, Zeng Z, Li W, Akinyemi IA, Yang H, Wu Q&. Genome sequence of a rice pest, the white-backed planthopper (Sogatella furcifera). Gigascience. 2017, 6(1):1-9.
5. Wang L, Tang N, Gao X, Guo D, Chang Z, Fu Y, Akinyemi IA, Wu Q&. Understanding the immune system architecture and transcriptome responses to southern rice black-streaked dwarf virus in Sogatella furcifera. Sci Rep. 2016, 6:36254.
6. Chang ZX, Tang N, Wang L, Zhang LQ, Akinyemi IA, Wu Q&. Identification and characterization of microRNAs in the white-backed planthopper, Sogatella furcifera. Insect Sci. 2016, 23(3):452-68.
3、病毒宏基因组学研究
宏基因组学(Metagenomics)是一种新兴的微生物研究技术,它突破了传统技术方法的局限,而直接以环境中所有微生物的遗传物质为研究对象,可以快速地鉴定出环境中所有的微生物.将其应用于病毒学的研究便形成了病毒宏基因组学。随着病毒宏基因组的广泛应用，人们发现了很多有意义的病毒,研究领域涉及到人类肠道、动物组织、水体和野生植物等,充分显示出其在病毒诊断、病原溯源、生物预警等方面的实用意义。
实验室相关论文：
1. Akinyemi IA, Wang F, Chang ZX, Wu Q&. Genome characterization of the newly identified maize-associated totivirus Anhui. Arch Virol. 2018, 163(10):2929-2931.
2. Yu H, Qi S, Chang Z, Rong Q, Akinyemi IA, Wu Q&. Complete genome sequence of a novel velarivirus infecting areca palm in China. Arch Virol. 2015, 160(9):2367-70.
3. Wu Q&, Ding SW&, Zhang Y, Zhu S&. Identification of viruses and viroids by next-generation sequencing and homology-dependent and homology-independent algorithms. Annu Rev Phytopathol. 2015, 53:425-44. （&共同通讯作者)
4. Zhang Z, Qi S, Tang N, Zhang X, Chen S, Zhu P, Ma L, Cheng J, Xu Y, Lu M, Wang H, Ding SW, Li S&, Wu Q&. Discovery of replicating circular RNAs by RNA-seq and computational algorithms. PLoS Pathog. 2014, 10(12):e1004553. （&共同通讯作者)
5. Wu Q#, Wang Y#, Cao M, Pantaleo V, Burgyan J , Li WX, Ding SW. Homology-Independent Discovery of Replicating Circular RNAs by Deep Sequencing and a New Computational Algorithm. Proc Natl Acad Sci U S A. 2012, 109:3938-3943.（# 共同第一作者）
6. Wu Q, Luo Y, Lu R, Lau N, Lai EC, Li WX, Ding SW. Virus discovery by deep sequencing and assembly of virus-derived small silencing RNAs. Proc Natl Acad Sci U S A. 2010, 107(4):1606-1611.
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