• May, 2022 Sun Y.-Y., Han X.-Y. and Cai W.-Q. have passed their thesis defence, Congratulations!
  • April, 2022 Our research work on Rodium catalyzed asymmetric synthesis of Chiraphos Derivatives was accepted by Chinese Chemical Letters. Congratulations to Sun, Y.-Y.
  • March, 2022 Our research work on nickel catalyzed hydrophosphinylation of conjugated enynes was accepted by Chemical Science. Congratulations to Zhang Y.-Q. and Han X.-Y.!
  • Feb, 2022 Our research work on nickel catalyzed benzylation of scondary phosphine oxide was accepted by Organic Letters. Congratulations to Cai W.-Q.!
  • Nov., 2021 Our research work on nickel catalyzed allylation of H-Phosphinates was accepted by Organic Letters. Congratulations to Qing Zhang!
  • Jul., 2021 Our research work on nickel catalyzed hydrophosphination of alkyne was accepted by Journal of American Chemical Society. Congrats Xuteng!
  • Jul., 2021 Our group website was online
Ni-catalyzed asymmetric C-P formation

Enantioenriched P-stereogenic phosphines have served as important chiral ligands for transition metals as well as organocatalysts. However, they are less studied compared to their counterparts that have chiral carbon backbones, in part due to their less availability and synthetic challenges. catalytic asymmetric synthesis of P-stereogenic phosphines has attracted broad attention during the past decades. Transition-metal-catalyzed asymmetric allylic substitution reactions have led to tremendous achievements in synthetic organic chemistry, serving as a powerful strategy to construct C−C and C−X bonds with chiral carbon centers. A nickel-catalyzed asymmetric allylation of secondary phosphine oxides for the synthesis of tertiary phosphine oxides was realized with high enantioselectivity. The dynamic kinetic asymmetric transformation of SPO was accomplished in the presence of nickel complex.