We are investigating the chemistry of fullerenes (C60 and C70) both in liquid phase and in solid state. The high-speed vibration milling (HSVM) technique is used for the soventless reactions of fullerenes. Fullerene derivatives with cationic or anionic groups are water-soluble. Some of the water-soluble derivatives have shown intersting biological properties. They have potential application in drugs. Currently, various water-soluble fullerene derivatives are being synthesized, their physical and biological properties will be explored.
(2) Green Organic Synthesis
Organic reaction under solvent-free conditions and microwave irradiation or high-speed vibration milling is the current focus.
(3) Theoretical Calculations Theoretical studies on the ongoing reactions in our research group are performed to better understand the reaction mechanisms.
(4) Electron Transfer Reactions
Collaborated with Professor You-Cheng Liu, electron transfer reactions involving coenzyme NADH models are being studied.
1. Guan-Wu Wang, Koichi Komatsu,* Yasujiro Murata, and Motoo Shiro, "Synthesis and X-Ray Structure of Dumb-Bell-Shaped C120", Nature 1997, 387, 583-586. (cover title, news reported by C & EN, news reported by Kyoto Newspaper)
2. Mark S. Meier,* Guan-Wu Wang, Robert C. Haddon, Carolyn Pratt. Brock, Michael A. Lloyd, and John P. Selegue, "Benzyne Adds Across a Closed 5-6 Ring Fusion in C70: Evidence for Bond Delocalization in Fullerenes", J. Am. Chem. Soc. 1998, 120, 2337-2342.
3.Guan-Wu Wang,* Ting-Hu Zhang, Er-Hong Hao, Li-Juan Jiao, Yasujiro Murata, and Koichi Komatsu, “Solvent-Free Reactions of Fullerenes with N-Alkylglycines with and without Aldehydes under High-Speed Vibration Milling”, Tetrahedron 2003, 59, 55-60.
4.
Guan-Wu
Wang,* Xin-Hao Zhang, Huan Zhan, Qing-Xiang Guo, and Yun-Dong Wu,
“Accurate Calculation, Prediction, and Assignment of 3He NMR
Chemical Shifts of Helium-3-Encapsulated Fullerenes and Fullerene
Derivatives”, J. Org. Chem.
2003, 68, 6732-6738.
5.Ting-Hu
Zhang, Ping Lu, Fan Wang, and Guan-Wu Wang,* “Reaction of [60]fullerene
with free radicals generated from active methylene compounds by manganese(III)
acetate”, Org. Biomol. Chem.
2003, 1, 4403-4407.
6.Guan-Wu
Wang, “Fullerene
Mechanochemistry”, in Encyclopedia of Nanoscience
and Nanotechnology, H. S. Nalwa, Ed., American
Scientific Publishers: Stevenson Ranch, Vol.
3, p. 557-565, 2004. (invited book chapter).
7. Ze Zhang, Ya-Wei Dong, Guan-Wu Wang,* and Koichi Komatsu, “Highly Efficient Mechanochemical Reactions of 1, 3-Dicarbonyl Compounds with Chalcones and Azachalcones Catalyzed by Potassium Carbonate”, Synlett 2004, 61-64.
8. Yu-Jin Li, Guan-Wu Wang,* Jia-Xing Li, and You-Cheng Liu, “Cycloaddition Reactions of Hydrofullerenes with Cyano-substituted Alkenes under Basic Conditions”, New J. Chem. 2004, 28, 1042-1046.
9. Ze Zhang, Guan-Wu Wang,* Chun-Bao Miao, Ya-Wei Dong, and Ye-Bing Shen, “Solid-state Radical Reactions of 1,3-Cyclohexanediones with in situ Generated Imines Mediated by Manganese(III) Acetate under Mechanical Milling Conditions”, Chem. Commun. 2004, 1832-1833.
10. Zhong-Xiu Chen, and Guan-Wu Wang,* “One-Pot Sequential Synthesis of Acetoxylated [60]Fullerene Derivatives”, J. Org. Chem. 2005, 70, 2380-2383.
Click HERE to see a full list of publications.
Professor Koich Komatsu
of Kyoto University
Professor Mark S. Meier
of University of Kentucky
Professor Martin Saunders of Yale
University
Professor James Cross of Yale University
Professor You-Cheng Liu of University of Science and Technology of China
Professor Qing-Xiang Guo of University of Science and Technology of China
Professor Zhi-Yong Wang of University of Science and Technology of China
Laboratory of Fullerene Chemistry and Green Organic Synthsis
Chinese Version & English Version
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