The Biomolecular Engineering Laboratory

in the School of Life Sciences at USTC

Positions for Associate Professors, Postdoctoral Associates, and Technicians are available.
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Ms. Meixia Cheng joined the lab as a technician.

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Selected Publications

A complete publication list can be found from Professor Sun's CV.

Peer-reviewed Articles:

16. Xu, Y., Yan, Y., Seeman, D., Sun, L., and Dubin, P. L. Multimerization and Aggregation of Native State Insulin: Effect of Zinc, Langmuir, DOI: 10.1021/la202902a


15. Chen, K., Xu, Y., Miranda, O. R., Dubin, P. L., Rotello, V., Sun, L., Guo, X. Electrostatic Selectivity in Protein-nanoparticle Interactions, Biomacromolecules, 12, 2552-2561, 2011.


14. Xu, Y., Mazzawi, M, Chen, K., Sun, L. and Dubin, P. L. Protein Purification by Polyelectrolyte Coacervation: Influence of Protein Charge Anisotropy on Selectivity, Biomacromolecules, 12, 1512-1522, 2011.

13. Sayut, D. J. and Sun, L. Creating Designer Laccases, Chemistry & Biology, 17, 918-920, 2010.

12. Sayut, D. J. and Sun, L. Slow activator degradation reduces the robustness of a coupled feedback loop oscillator, Molecular Biosystems, 6, 1469-1474, 2010

11. Kambam, P. K. R., Eriksen, D., Lajoie, J., Sayut, D. J. and Sun, L. Altering the Substrate Specificity of RhlI by Directed Evolution, ChemBioChem, 10, 553-558, 2009.

10. Sayut, D. J., Niu, Y. and Sun, L. Enhancing the Logical Output of a Genetic AND Gate, Applied and Environmental Microbiology, 75, 637-642, 2009.

9. Sayut, D. J., Kambam, P. K. R. and Sun, L. Enzyme Replacement Therapy for Lysosomal Storage Disorders. Recent Patents on Biomedical Engineering, 1, 141-147, 2008.

8. Cirino, P. C. and Sun, L. Advancing Biocatalysis through Enzyme, Cellular, and Platform Engineering, Biotechnology Progress, 24, 515-519, 2008 (Meeting Review).

7. Kambam, P., Sayut, D. J., Niu, Y., Eriksen, D. T., and Sun, L. Directed Evolution of LuxI for Enhanced OHHL Production, Biotechnology and Bioengineering, 101, 263-272, 2008.

6. Kambam, P., Henson, M. A., and Sun, L. Design And Mathematical Modeling Of A Synthetic Symbiotic Ecosystem, IET Systems Biology, 2, 33-38, 2008 .

5. Sayut, D. J., Kambam, P., and Sun, L. Engineering And Applications Of Genetic Switches, Molecular BioSystems, 3, 385-840, 2007 (Invited Review).

4. Sayut, D. J., Kambam, P., and Sun, L. Noise And Kinetics Of Positive Feedback Loops, Biochemical and Biophysical Research Communications, 363, 667-673, 2007.

3. Sayut, D. J., Niu, Y., and Sun, L., Construction and Engineering of Positive Feedback Loops. ACS Chemical Biology. 1, 692-696, 2006.

2. Sun, L., Bulter, T., Alcalde, M., Petrounia, I. P. and Arnold, F. H., Modification of galactose oxidase to introduce glucose 6-oxidase activity. ChemBioChem. 3, 781-783, 2002.

1. Sun, L., Petrounia, I. P., Yagasaki, M., Bandara, G. and Arnold, F. H. Expression and stabilization of galactose oxidase in Escherichia coli by directed evolution. Protein Engineering. 14, 699-704, 2001.


Book Chapters:

6. Sayut, D. J., Herrick, W. G. and Sun L. Applications of Bacterial Quorum-Sensing Systems in Synthetic Biology. In Synthetic & Integrative Biology: Parsts & Systems, Design Theory & Applications, 2011, 61-76, (Gevona, J. T. Ed), Nova Scientific Publisher, Inc. Hauppauge, NY.

5. Sayut, D. J., Niu, Y. and Sun, L. Engineering the Logical Properties of a Genetic AND Gate. In Methods in Molecular Biology, 2011, 743, 175-184, Nanoscale Biocatalysis: Methods and Protocols. (Wang, P. Ed), Humanna Press Inc. Totowa, NJ.

4. Sayut, D. J., Kambam, P. K. R., Herrick, W. G. and Sun, L. Enzyme Production in Escherichia coli. In Manual of Industrial Microbiology and Biotechnology, Third Edition, (Baltz, R. H., Davies, J. E., and Demain, A. L. Eds), ASM Press, Washington, DC.

3. Sun, L. and Yagasaki, M. Screen for Oxidase by Detection of Hydrogen Peroxide with Horseradish Peroxidase. In Methods in Molecular Biology, 230, 177-182, 2003. Directed Enzyme Evolution: Screening and Selection Methods. (Arnold, F. H. and Georgiou, G. Eds), Humanna Press Inc. Totowa, NJ.

2. Salazer, O. and Sun, L. Mutant Library Analysis. In Methods in Molecular Biology, 230, 85-98, 2003. Directed Enzyme Evolution: Screening and Selection Methods. (Arnold, F. H. and Georgiou, G. Eds), Humanna Press Inc. Totowa, NJ.

1. Georgescu, R., Bandara, G. and Sun, L. Saturation Mutagenesis. In Methods in Molecular Biology, 230, 75-84, 2003. Directed Evolution: Library Creation.  (Arnold, F. H. and Georgiou, G. Eds.), Humana Press Inc., Totowa, NJ.

Patents:

3. Arnold, F. H., Petrounia, I. P. and Sun, L.  Directed Evolution of Oxidase Enzymes. USA Patent No. US7098010B1

2. Arnold, F. H., Petrounia, I. P. and Sun, L.  Directed Evolution of Galactose Oxidase. USA Patent No. US7115403B1

1. Arnold, F. H., Sun, L. and Petrounia, I. P. Novel Glucose 6-Oxidase. USA Patent No. US7220563
All Rights Reserved. Last Updated: August 03, 2010.