The Laboratory of Immunology and Imaging

免疫动态成像实验室

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   Publications:

1. Li L, Jiao Q, Yang Q,Lu H, Zhou X, Zhang Q, Zhang F, Li H, Tian Z, Zeng Z.A bladder-blood immune barrier constituted by suburothelial perivascular macrophages restrains uropathogen dissemination. Immunity. 2025 Mar 11;58(3):568-584.e6.

2. Li S, Yao Q, Li J, Yang H, Qian R, Zheng M, Wu N, Jiang H, Li L, Zeng Z. Inhibition of Neutrophil Swarming by Type I Interferon promotes Intracellular Bacterial Evasion. Nature Communications, 2024 Oct 7;15(1):8663.

3. Liu W, Zhou X, Yao Q, Chen C, Zhang Q, Ding K, Li L, Zeng Z.In Situ Expansion and Reprogramming of Kupffer Cells Elicits Potent Tumoricidal Immunity against Liver Metastasis. Journal Of Clinical Investigation. 2023 Feb 23:e157937. 

4.  Li L, Zeng Z.Live Imaging of Innate and Adaptive Immune Responses in the Liver.  Frontiers in Immunology. 2020 Sep 17; 11:564768.

5. Zeng Z, Surwarrd BG,Wong CH, Guettler C, Petri B, Burkhard R, Wyss M, Moual HL, Devinney R, Thompson GC, Blackwood J, Joffe AR,  McCoy KD, Jenne CN, Kubes P. Sex-hormone-driven innate antibodies protect females and infants against EPEC infection. Nature Immunology.2018; 19: 1100-1111.

6. Zeng Z, Surwarrd BG,Wong CH, Geoghegan AJ, Jenne CN, Kubes P. CRIg Functions as a Macrophage Pattern Recognition Receptor to Directly Bind and Capture Blood-Borne Gram-Positive Bacteria. Cell Host&Microbe. 2016; 20 (1):99-106.

7. Zeng Z, Li L, Chen Y, Wei H, Sun R, Tian Z. Interferon-gamma Facilitates Hepatic Antiviral T cell Retention for the Maintenance of Liver-induced Systemic Tolerance. Journal of Experimental Medicine. 2016; 213(6):1079-93.

8. Zeng Z, Kong X, Li F, Wei H, Sun R, Tian Z. IL-12-based vaccination therapy reverses liver-induced systemic tolerance in a mouse model of hepatitis B virus carrier. Journal of Immunology 2013, 191(8): 4184-4193.

9. An H, Qian C, Huang Y, Li J, Tian X, Feng J, Hu J, Fang Y, Jiao F, Zeng Y, Huang X, Meng X, Liu X, Lin X, Zeng Z, Guilliams M, Beschin A,et al.Functional Vulnerability of Liver Macrophages to Capsules Defines Virulence of Blood-borne Bacteria.Journal of Experimental Medicine. 2022 Apr 4;219(4):e20212032.

10.  Zhou H,  Zeng Z, Wang F.Intravital Microscopy Imaging of Invariant Natural Killer T-Cell Dynamics in the Liver Using CXCR6-eGFP Transgenic Mice. Methods in Molecular Biology. 2021;2388:149-156.

11. Pose E, Coll M, Martínez-Sánchez C, Zeng Z, Surewaard BGJ, Català C, Velasco-de Andrés M, Lozano JJ, Ariño S, Fuster D, Niñerola-Bazán A, Graupera I, Muñoz É, Lozano F, Sancho-Bru P, Kubes P, Ginès P.Programmed Death Ligand 1 Is Overexpressed in Liver Macrophages in Chronic Liver Diseases, and Its Blockade Improves the Antibacterial Activity Against Infections. Hepatology. 2021 Jul;74(1):296-311.

12. Guo C, Cai P, Jin L, Sha Q, Yu Q, Zhang W, Jiang C, Liu Q, Zong D, Li K, Fang J, Lu F, Wang Y, Li D, Lin J, Li L, Zeng Z, Tong X, Wei H, Qu K.Single-cell Profiling of the Human Decidual Immune Microenvironment in Patients with Recurrent Pregnancy Loss. Cell Discovery. 2021 Jan 4;7(1):1. 

13. Li S, Li M, Huo S, Wang Q, Chen J, Ding S, Zeng Z, Zhou W, Wang Y, Wang J.Voluntary-Opsonization-Enabled Precision Nanomedicines for Inflammation Treatment.Advanced Materials. 2021 Jan;33(3):e2006160.

14. Hilscher MB, Sehrawat T, Arab Verdugo JP, Zeng Z, Gao J, Liu M, et al. Mechanical Stretch Increases Expression of CXCL1 in Liver Sinusoidal Endothelial Cells to Recruit Neutrophils, Generate Sinusoidal Microthombi, and Promote Portal Hypertension. Gastroenterology 2019, 157:193-209.

15. Thanabalasuriar A, Scott BNV, Peiseler M, Willson ME, Zeng Z, Warrener P, Keller AE, et al., Neutrophil Extracellular Traps Confine Pseudomonas aeruginosa Ocular Biofilms and Restrict Brain Invasion. Cell Host & Microbe 2019, 25(4):526-536.

16. Naumenko V, Van S, Dastidar H, Kim DS, Kim SJ, Zeng Z, et al. Visualizing Oncolytic Virus-Host Interactions in Live Mice Using Intravital Microscopy. Molecular Therapy Oncolytics 2018, 10: 14-27.

17. Surewaard BGJ, Thanabalasuriar A, Zeng Z, Tkaczyk C, Cohen TS, Bardoel BW, et al. α-Toxin Induces Platelet Aggregation and Liver Injury during Staphylococcus aureus Sepsis. Cell Host & Microbe 2018, 24(2): 271-284 e273.

18. Kasturirangan S, Rainey GJ, Xu L, Wang X, Portnoff A, Chen TZ, Fazenbaker C, Zhong H, Bee J, Zeng Z. et al. Targeted Fcgamma Receptor (FcgammaR)-mediated Clearance by a Biparatopic Bispecific Antibody. The Journal of Biological Chemistry 2017, 292(10): 4361-4370.

19. Li L, Zeng Z, Qi Z, Wang X, Gao X, Wei H, Sun R, Tian Z.Natural Killer Cells-Produced IFN-γ Improves Bone Marrow-Derived Hepatocytes Regeneration in Murine Liver Failure Model. Scientific Reports. 2015 Sep 8;5:13687.

20. Dal-Secco D, Wang J, Zeng Z, Kolaczkowska E, Wong CH, Petri B, et al. A dynamic spectrum of monocytes arising from the in situ reprogramming of CCR2+ monocytes at a site of sterile injury. Journal of Experimental Medicine. 2015, 212(4): 447-456.